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GSK2795039

Chemical Structure : GSK2795039

CAS No.: 1415925-18-6

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GSK2795039 (GSK 2795039, GSK-2795039)

Catalog No.: PC-45569Not For Human Use, Lab Use Only.

GSK2795039 (GSK 2795039) is a potent and selective inhibitor of NOX2 (NADPH oxidase 2) with pIC50 of 6.57.

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5 mg $188 In stock
10 mg $298 In stock
25 mg $498 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

GSK2795039 (GSK 2795039) is a potent and selective inhibitor of NOX2 (NADPH oxidase 2) with pIC50 of 6.57.
GSK-2795039 exhibits good selectivity for NOX2 over other NOX isoforms, xanthine oxidase and eNOS.
GSK-2795039 abolishes the production of ROS by activated NOX2 enzyme in a paw inflammation model of acute pancreatitis.

Physicochemical Properties

M.Wt 450.5565
Formula C23H26N6O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 32 mg/mL
Chemical Name/SMILES

1H-Pyrazole-3-sulfonamide, N-[3-(2,3-dihydro-1-methyl-1H-indol-6-yl)-1-(1-methylethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-methyl-

References

1. Hirano K, et al. Antioxid Redox Signal. 2015 Aug 10;23(5):358-74.

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