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AQ-101

Chemical Structure : AQ-101

CAS No.: 1353384-61-8

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AQ-101 (AQ101)

Catalog No.: PC-63188Not For Human Use, Lab Use Only.

AQ-101 is a novel small-molecule anthraquinone analog that induces MDM2 protein degradation (Kd=0.37 uM) through a self-ubiquitination and proteasome-mediated mechanism, leading to activation of p53.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AQ-101 is a novel small-molecule anthraquinone analog that induces MDM2 protein degradation (Kd=0.37 uM) through a self-ubiquitination and proteasome-mediated mechanism, leading to activation of p53.
    AQ-101 induces apoptosis of acute lymphoblastic leukemia (ALL) especially those with a wild-type p53 phenotype and MDM2 expression in vitro and in vivo.
    AQ-101 inhibits development of ALL in nude or SCID mice with a human ALL xenograft.

    Physicochemical Properties

    M.Wt 331.708
    Formula C16H10ClNO5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-chloro-N-(4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracen-2-yl)acetamide

    References

    1. Gu L, et al. Mol Cancer Ther. 2018 Feb;17(2):497-507.

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