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Chemical Structure : AQX-MN100
Catalog No.: PC-20548Not For Human Use, Lab Use Only.
AQX-MN100 (ZPR-MN100) is a small-molecule agonist of SHIP1, enhances SHIP1 enzyme activity in vitro.
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AQX-MN100 (ZPR-MN100) is a small-molecule agonist of SHIP1, enhances SHIP1 enzyme activity in vitro.
AQX-MN100 selectively inhibited TNFα production from SHIP1+/+ but not SHIP1−/− macrophages with EC50 of 0.3-0.6 uM.
AQX-MN100 efficiently inhibited the LPS-induced elevation of plasma TNFα levels in the mouse endotoxemia model.
AQX-MN100 dramatically inhibited DNFB-induced neutrophil-specific myeloperoxidase (MPO) in sensitized mice, also inhibited DNFB-induced inflammation.
| M.Wt | 312.50 | |
| Formula | C22H32O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Christopher J Ong, et al. Blood. 2007 Sep 15;110(6):1942-9.
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