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AQX-MN100

Chemical Structure : AQX-MN100

CAS No.: 1000009-73-3

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AQX-MN100 (ZPR-MN100)

Catalog No.: PC-20548Not For Human Use, Lab Use Only.

AQX-MN100 (ZPR-MN100) is a small-molecule agonist of SHIP1, enhances SHIP1 enzyme activity in vitro.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

AQX-MN100 (ZPR-MN100) is a small-molecule agonist of SHIP1, enhances SHIP1 enzyme activity in vitro.
AQX-MN100 selectively inhibited TNFα production from SHIP1+/+ but not SHIP1−/− macrophages with EC50 of 0.3-0.6 uM.
AQX-MN100 efficiently inhibited the LPS-induced elevation of plasma TNFα levels in the mouse endotoxemia model.
AQX-MN100 dramatically inhibited DNFB-induced neutrophil-specific myeloperoxidase (MPO) in sensitized mice, also inhibited DNFB-induced inflammation.

Physicochemical Properties

M.Wt 312.50
Formula C22H32O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

OC1=CC2=C(C(C)=C1)[C@]3(C)CC[C@](C(C)(C)CCC4)([H])[C@@]4(C)[C@@]3([H])C2

References

1. Christopher J Ong, et al. Blood. 2007 Sep 15;110(6):1942-9.

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