Chemical Structure : AR-001
CAS No.:
681475-23-0
AR-001
(AR001)
Catalog No.: PC-22838Not For Human Use, Lab Use Only.
AR-001 is a selective adenosine A1 receptor agonist with EC50 of 9.35 uM in HEK293-aeqα15/ADORA1 cells, increases adenosine A1 receptor expression and mRNA level in the hypothalamus of mice, exhibits hypnotic efficacy.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
AR-001 is a selective adenosine A1 receptor agonist with EC50 of 9.35 uM in HEK293-aeqα15/ADORA1 cells, increases adenosine A1 receptor expression and mRNA level in the hypothalamus of mice, exhibits hypnotic efficacy.
AR-001 significantly affects the onset latency to sleep and total sleep time in mice.
AR-001 decreases the neuronal activity in wake-promoting brain regions and increase the neuronal activity in hypnotic brain regions, which is significantly reversed by the highly-selective adenosine A1 receptor antagonist DPCPX.
AR-001 treatment induced mRNA expression of adenosine A1 receptor and activation of NF-κB in hypothalamus of the mouse brain.
Physicochemical Properties
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M.Wt
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268.32
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Formula
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C15H16N4O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N2-ethyl-N4-(furan-2-ylmethyl)quinazoline-2,4-diamine
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References
1. Kim S, et al. Eur J Pharmacol. 2024 Jul 30:176847.
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