Catalog No.: PC-21824Not For Human Use, Lab Use Only.
AR9281 (APAU) is a potent, selective and orally active soluble epoxide hydrolase (sEH) inhibitor with IC50 of 8 nM and 3 nM for human and mouse sEH enzyme, respectively.
AR9281 (APAU) is a potent, selective and orally active soluble epoxide hydrolase (sEH) inhibitor with IC50 of 8 nM and 3 nM for human and mouse sEH enzyme, respectively. AR9281 is highly selective with no inhibitory activity against microsomal epoxide hydrolase or an extended panel of ca.150 other enzyme and receptor targets at 10 uM. AR9281 attenuates the enhanced glucose excursion following an intraperitoneal glucose tolerance test in mouse model of diet induced obesity. AR9281 also attenuates the increase in blood pressure in angiotensin-II-induced hypertension in rats.
Physicochemical Properties
M.Wt
319.45
Formula
C18H29N3O2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
1-(1-Acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea
References
1. Anandan SK, et al. Bioorg Med Chem Lett. 2011 Feb 1;21(3):983-8.
2. Zhang LN, et al. Eur J Pharmacol. 2011 Mar 1;654(1):68-74.
