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ARH3 inhibitor 26

Chemical Structure : ARH3 inhibitor 26

CAS No.: 767583-90-4

ARH3 inhibitor 26 (AI26)

Catalog No.: PC-72031Not For Human Use, Lab Use Only.

ARH3 inhibitor 26 (AI26) is a small molecule ADP-ribosylhydrolase ARH3 inhibitor that binds to the catalytic pocket of ARH3 and inhibits the enzymatic activity of ARH3 with IC50 of 2.41 uM in vitro.

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    Biological Activity

    ARH3 inhibitor 26 (AI26) is a small molecule ADP-ribosylhydrolase ARH3 inhibitor that binds to the catalytic pocket of ARH3 and inhibits the enzymatic activity of ARH3 with IC50 of 2.41 uM in vitro.
    ARH3 inhibitor 26 (AI26) inhibited hydrolysis of DNA damage-induced ADP-ribosylation leading to defects in DNA damage repair.
    Tumor cells with DNA damage repair defects were hypersensitive to AI26 treatment, as well as combinations of AI26 and other DNA-damaging agents such as camptothecin and doxorubicin.

    Physicochemical Properties

    M.Wt 420.472
    Formula C26H20N4O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    2-[4-[(1E)-2-[5-(Aminoiminomethyl)-2-benzofuranyl]ethenyl]phenyl]-5-benzofurancarboximidamide

    References

    1. Xiuhua Liu, et al. J Biol Chem. 2020 Oct 2;295(40):13838-13849.

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