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ARN-5187

Chemical Structure : ARN-5187

CAS No.: 1287451-26-6

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ARN-5187 (ARN5187;ARN 5187)

Catalog No.: PC-61357Not For Human Use, Lab Use Only.

ARN-5187 (ARN5187) is a lysosomotropic REV-ERB ligand that has a dual inhibitory activity toward REV-ERB-mediated transcriptional regulation and autophagy.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ARN-5187 (ARN5187) is a lysosomotropic REV-ERB ligand that has a dual inhibitory activity toward REV-ERB-mediated transcriptional regulation and autophagy.
    ARN-5187 relieves REV-ERB-mediated transcriptional repression, significantly increases autophagy-associated protein p62 in treated cells.
    ARN-5187 disrupts lysosomal function, blocks the autophagy process at the late stage, and reduces cancer cell viability.
    ARN-5187 a novel dual autophagy/REV-ERB inhibitor more cytotoxic than chloroquine.

    Physicochemical Properties

    M.Wt 397.538
    Formula C24H32FN3O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-[[[1-(2-Fluorophenyl)cyclopentyl]amino]methyl]-2-[(4-methyl-1-piperazinyl)methyl]phenol

    References

    1. De Mei C, et al. Oncogene. 2015 May 14;34(20):2597-608.

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