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Chemical Structure : ARN077
CAS No.: 1373625-34-3
Catalog No.: PC-62873Not For Human Use, Lab Use Only.
ARN077 is the first potent, selective N-acylethanolamine acid amidase (NAAA) inhibitor with IC50 of 7 nM on both rat NAAA and human NAAA.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $288 | In stock | |
| 10 mg | $438 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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ARN077 is the first potent, selective N-acylethanolamine acid amidase (NAAA) inhibitor with IC50 of 7 nM on both rat NAAA and human NAAA.
ARN077 attenuates heat hyperalgesia and mechanical allodynia elicited in mice by carrageenan injection or sciatic nerve ligation in a dose-dependent manner, reverses the allodynia caused by ultraviolet B radiation in rats.
ARN077 also suppresses DNFB-induced inflammation pruritus in mouse model of allergic dermatitis.
| M.Wt | 291.347 | |
| Formula | C16H21NO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
5-Phenylpentyl ((2S,3R)-2-methyl-4-oxooxetan-3-yl)carbamate |
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1. Ponzano S, et al. J Med Chem. 2013 Sep 12;56(17):6917-34.
2. Sasso O, et al. Pain. 2013 Mar;154(3):350-60.
3. Romeo E, et al. ACS Chem Biol. 2015 Sep 18;10(9):2057-64.
4. Sasso O, et al. J Invest Dermatol. 2018 Mar;138(3):562-569.
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