ARN077 is the first potent, selective N-acylethanolamine acid amidase (NAAA) inhibitor with IC50 of 7 nM on both rat NAAA and human NAAA.
ARN077 attenuates heat hyperalgesia and mechanical allodynia elicited in mice by carrageenan injection or sciatic nerve ligation in a dose-dependent manner, reverses the allodynia caused by ultraviolet B radiation in rats.
ARN077 also suppresses DNFB-induced inflammation pruritus in mouse model of allergic dermatitis.
