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ARN15381

Chemical Structure : ARN15381

CAS No.: 2650065-24-8

ARN15381 (ARN 15381)

Catalog No.: PC-47021Not For Human Use, Lab Use Only.

ARN15381 is a potent, multitarget FAAH inhibitor/D3 partial agonist with low nanomolar range activity, decreases nicotine self-administration in male rats.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ARN15381 is a potent, multitarget FAAH inhibitor/D3 partial agonist with low nanomolar range activity, decreases nicotine self-administration in male rats.
ARN15381 dose dependently decreased self-administration of a nicotine dose at the top of the nicotine dose/response (D/R) curve, while it did not affect self-administration of a nicotine dose laying on the descending limb of the D/R curve.

Physicochemical Properties

M.Wt 534.906
Formula C27H30Cl3N3O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

[1,1'-biphenyl]-4-yl (4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)carbamate hydrochloride

References

1. Veronica Lunerti, et al. Eur J Pharmacol. 2022 Jun 8;928:175088.

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