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ARN15381

Chemical Structure : ARN15381

CAS No.: 2650065-24-8

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ARN15381 (ARN 15381)

Catalog No.: PC-47021Not For Human Use, Lab Use Only.

ARN15381 is a potent, multitarget FAAH inhibitor/D3 partial agonist with low nanomolar range activity, decreases nicotine self-administration in male rats.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ARN15381 is a potent, multitarget FAAH inhibitor/D3 partial agonist with low nanomolar range activity, decreases nicotine self-administration in male rats.
    ARN15381 dose dependently decreased self-administration of a nicotine dose at the top of the nicotine dose/response (D/R) curve, while it did not affect self-administration of a nicotine dose laying on the descending limb of the D/R curve.

    Physicochemical Properties

    M.Wt 534.906
    Formula C27H30Cl3N3O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    [1,1'-biphenyl]-4-yl (4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)carbamate hydrochloride

    References

    1. Veronica Lunerti, et al. Eur J Pharmacol. 2022 Jun 8;928:175088.

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