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ARN19689

Chemical Structure : ARN19689

CAS No.: 2320521-34-2

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ARN19689 (ARN-19689)

Catalog No.: PC-72102Not For Human Use, Lab Use Only.

ARN19702 (ARN-19702) is potent, selective, non-covalent inhibitor of N-Acylethanolamine acid amidase (NAAA) with IC50 of 42 nM (h-NAAA).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ARN19702 (ARN-19702) is potent, selective, non-covalent inhibitor of N-Acylethanolamine acid amidase (NAAA) with IC50 of 42 nM (h-NAAA). ARN19702 showed a very high selectivity toward both human FAAH and human acid ceramidase (AC), both IC50>30 uM.
    ARN1970 binds to human NAAA in a non-covalent manner.
    ARN1970 shows a good efficacy and biochemical profile, and preliminary in vitro ADME properties.
    ARN1970 represents a valuable tool to be further investigated in animal models of inflammatory conditions.

    Physicochemical Properties

    M.Wt 421.516
    Formula C19H27N5O4S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (1R,3r,5S)-8-((3,5-Dimethyl-1H-pyrazol-4-yl)sulfonyl)-3-((5-(ethoxymethyl)pyrazin-2-yl)oxy)-8-azabicyclo[3.2.1]octane

    References

    1. Paolo Di Fruscia, et al. J Med Chem. 2021 Sep 23;64(18):13327-13355.

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