ARN19702 (ARN-19702) is potent, selective, orally active, reversible inhibitor of N-Acylethanolamine acid amidase (NAAA) with IC50 of 230 nM.
ARN19702 produces remarkable protective effects against multiple sclerosis in mice.
ARN19702 reduced nociception associated with paclitaxel-induced neuropathy without development of subacute antinociceptive tolerance.
ARN19702 (30 mg/kg, oral) did not produce place preference or alter exploratory motor behavior in male mice.
