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ARN726

Chemical Structure : ARN726

CAS No.: 1628343-77-0

ARN726 (ARN 726, ARN-726)

Catalog No.: PC-62874Not For Human Use, Lab Use Only.

ARN726 is a potent, selective, orally bioavailable N-acylethanolamine acid amidase (NAAA) inhibitor with IC50 of 63 nM (r-NAAA) and 27 nM (h-NAAA).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ARN726 is a potent, selective, orally bioavailable N-acylethanolamine acid amidase (NAAA) inhibitor with IC50 of 63 nM (r-NAAA) and 27 nM (h-NAAA).
ARN726 shows no interaction with a panel of 28 biologically relevant targets comprising lipid-metabolizing and inflammation-related enzymes.
ARN726 exerts profound anti-inflammatory effects in both mouse models and human macrophages.

Physicochemical Properties

M.Wt 268.357
Formula C14H24N2O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-Cyclohexylbutyl-N-[(S)-2-oxoazetidin-3-yl]carbamate

References

1. Ribeiro A, et al. ACS Chem Biol. 2015 Aug 21;10(8):1838-46.

2. Bonezzi FT, et al. J Pharmacol Exp Ther. 2016 Mar;356(3):656-63.

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