ARN726 is a potent, selective, orally bioavailable N-acylethanolamine acid amidase (NAAA) inhibitor with IC50 of 63 nM (r-NAAA) and 27 nM (h-NAAA).
ARN726 shows no interaction with a panel of 28 biologically relevant targets comprising lipid-metabolizing and inflammation-related enzymes.
ARN726 exerts profound anti-inflammatory effects in both mouse models and human macrophages.
