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Chemical Structure : ARSA-IN-1r
Catalog No.: PC-72504Not For Human Use, Lab Use Only.
ARSA-IN-1r (ARSAi) is the first reversible inhibitor of human Arylsulfatase A (ARSA) with SPR KD of 21 uM and IC50 of 13.2 uM.
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ARSA-IN-1r (ARSAi) is the first reversible inhibitor of human Arylsulfatase A (ARSA) with SPR KD of 21 uM and IC50 of 13.2 uM.
Compound 1r induced 20% sperm death at 25 μM and also impaired sperm motility mediated by ROS production.
ARSA-IN-1r markedly decreased the in vitro oocyte fertilization by mouse sperm.
ARSA-IN-1r (ARSAi) is a chemical tool that will enable better exploration of ARSA's biological role in fertilization.
| M.Wt | 326.307 | |
| Formula | C21H10O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Silvia Caroselli, et al. ACS Chem Biol. 2020 Jun 19;15(6):1349-1357.
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