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ARSA-IN-1r

Chemical Structure : ARSA-IN-1r

CAS No.: 2097815-91-1

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ARSA-IN-1r (ARSAi)

Catalog No.: PC-72504Not For Human Use, Lab Use Only.

ARSA-IN-1r (ARSAi) is the first reversible inhibitor of human Arylsulfatase A (ARSA) with SPR KD of 21 uM and IC50 of 13.2 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ARSA-IN-1r (ARSAi) is the first reversible inhibitor of human Arylsulfatase A (ARSA) with SPR KD of 21 uM and IC50 of 13.2 uM.
Compound 1r induced 20% sperm death at 25 μM and also impaired sperm motility mediated by ROS production.
ARSA-IN-1r markedly decreased the in vitro oocyte fertilization by mouse sperm.
ARSA-IN-1r (ARSAi) is a chemical tool that will enable better exploration of ARSA's biological role in fertilization.

Physicochemical Properties

M.Wt 326.307
Formula C21H10O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4H-benzo[h]naphtho[1,2-c]chromene-1,4,14-trione

References

1. Silvia Caroselli, et al. ACS Chem Biol. 2020 Jun 19;15(6):1349-1357.

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