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Chemical Structure : ART812
CAS No.: 2607138-82-7
Catalog No.: PC-49362Not For Human Use, Lab Use Only.
ART812 (ART-812) is a selective small molecule DNA polymerase theta (Polθ) in vivo probe with IC50 of 7.6 nM, and IC50 of 240 nM for cell based microhomology-mediated end joining (MMEJ).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 1 mg | $178 | In stock | |
| 5 mg | $398 | In stock | |
| 10 mg | Get quote | ||
| 25 mg | Get quote | ||
| 50 mg | Get quote |
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ART812 (ART-812) is a selective small molecule DNA polymerase theta (Polθ) in vivo probe with IC50 of 7.6 nM, and IC50 of 240 nM for cell based microhomology-mediated end joining (MMEJ).
ART812 recapitulates the phenotype of Polθ loss and is efficacious in a model of PARP inhibitor resistant TNBC in vivo.
| M.Wt | 461.798 | |
| Formula | C19H16ClF4N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(2S,3S,4S)-N-(3-chloro-4-fluorophenyl)-3,4-dihydroxy-N-methyl-1-(6-methyl-4-(trifluoromethyl)pyridin-2-yl)-5-oxopyrrolidine-2-carboxamide |
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1. Martin L Stockley, et al. J Med Chem. 2022 Oct 6. doi: 10.1021/acs.jmedchem.2c01142.
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