ARUK2007145 | PI5P4Kα/γ inhibitor | Probechem Biochemicals

Chemical Structure : ARUK2007145

ARUK2007145 (ARUK 2007145)

Catalog No.: PC-21274Not For Human Use, Lab Use Only.

ARUK2007145 is a potent, selective and cell-active PI5P4Kα/γ dual inhibitor with pIC50 of 7.3/8.1, resepctively, shows no activity against PI5P4Kβ.

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Biological Activity

ARUK2007145 is a potent, selective and cell-active PI5P4Kα/γ dual inhibitor with pIC50 of 7.3/8.1, resepctively, shows no activity against PI5P4Kβ.
ARUK2007145 shows good activity in the InCELL Pulse target engagement assay (PI5P4Kγ pIC50=7.3).
ARUK2007145 shows a good dual activity in the ADP-Glo assays showing similar activities for PI5P4Kγ+ and PI5P4Kα (fold-selectivity=5).

Physicochemical Properties

M.Wt	384.90
Formula	C18H13ClN4S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(2-chloropyridin-3-yl)-N-(4-(methylthio)phenyl)thieno[3,2-d]pyrimidin-4-amine

References

1. Gregory G Aldred, et al. RSC Med Chem. 2023 Aug 23;14(10):2035-2047.

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ARUK2007145 (ARUK 2007145)

Biological Activity

Physicochemical Properties

References

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