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ARUK2007145

Chemical Structure : ARUK2007145

CAS No.:

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ARUK2007145 (ARUK 2007145)

Catalog No.: PC-21274Not For Human Use, Lab Use Only.

ARUK2007145 is a potent, selective and cell-active PI5P4Kα/γ dual inhibitor with pIC50 of 7.3/8.1, resepctively, shows no activity against PI5P4Kβ.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ARUK2007145 is a potent, selective and cell-active PI5P4Kα/γ dual inhibitor with pIC50 of 7.3/8.1, resepctively, shows no activity against PI5P4Kβ.
    ARUK2007145 shows good activity in the InCELL Pulse target engagement assay (PI5P4Kγ pIC50=7.3).
    ARUK2007145 shows a good dual activity in the ADP-Glo assays showing similar activities for PI5P4Kγ+ and PI5P4Kα (fold-selectivity=5).

    Physicochemical Properties

    M.Wt 384.90
    Formula C18H13ClN4S2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    6-(2-chloropyridin-3-yl)-N-(4-(methylthio)phenyl)thieno[3,2-d]pyrimidin-4-amine

    References

    1. Gregory G Aldred, et al. RSC Med Chem. 2023 Aug 23;14(10):2035-2047.

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