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AS1134900

Chemical Structure : AS1134900

CAS No.: 149760-98-5

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AS1134900 (AS 1134900)

Catalog No.: PC-49092Not For Human Use, Lab Use Only.

AS1134900 is a potent, highly selective, allosteric inhibitor of NADP+-dependent malic enzyme 1 (ME1), uncompetitively inhibits ME1 activity in the presence of its substrates NADP+ and malate, binds outside the ME1 active site in a novel allosteric site.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AS1134900 is a potent, highly selective, allosteric inhibitor of NADP+-dependent malic enzyme 1 (ME1), uncompetitively inhibits ME1 activity in the presence of its substrates NADP+ and malate, binds outside the ME1 active site in a novel allosteric site.

    Physicochemical Properties

    M.Wt 466.567
    Formula C25H22N8S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(2-(1H-tetrazol-5-yl)phenyl)-6-((7-methyl-2-propyl-4H-imidazo[4,5-b]pyridin-4-yl)methyl)benzo[d]thiazole

    References

    1. Tomohiro Yoshida, et al. Biochemistry. 2022 Jul 12. doi: 10.1021/acs.biochem.2c00123.

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