AS1134900 | ME1 inhibitor | Probechem Biochemicals

Chemical Structure : AS1134900

AS1134900 (AS 1134900)

Catalog No.: PC-49092Not For Human Use, Lab Use Only.

AS1134900 is a potent, highly selective, allosteric inhibitor of NADP+-dependent malic enzyme 1 (ME1), uncompetitively inhibits ME1 activity in the presence of its substrates NADP+ and malate, binds outside the ME1 active site in a novel allosteric site.

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Biological Activity

AS1134900 is a potent, highly selective, allosteric inhibitor of NADP+-dependent malic enzyme 1 (ME1), uncompetitively inhibits ME1 activity in the presence of its substrates NADP+ and malate, binds outside the ME1 active site in a novel allosteric site.

Physicochemical Properties

M.Wt	466.567
Formula	C25H22N8S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2-(1H-tetrazol-5-yl)phenyl)-6-((7-methyl-2-propyl-4H-imidazo[4,5-b]pyridin-4-yl)methyl)benzo[d]thiazole

References

1. Tomohiro Yoshida, et al. Biochemistry. 2022 Jul 12. doi: 10.1021/acs.biochem.2c00123.

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AS1134900 (AS 1134900)

Biological Activity

Physicochemical Properties

References

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