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AS1411

Chemical Structure : AS1411

CAS No.: 301636-59-9

AS1411 (AGRO100)

Catalog No.: PC-22760Not For Human Use, Lab Use Only.

AS1411 is a quadruplex-forming oligonucleotide aptamer that targets nucleolin, inhibits cancer cell proliferation.

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Biological Activity

AS1411 is a quadruplex-forming oligonucleotide aptamer that targets nucleolin, inhibits cancer cell proliferation.
AS1411 decreases level of PRMT5 in the nucleus of DU145 human prostate cancer cells, but increases PRMT5 in the cytoplasm.
AS1411 causes relocalization of the nucleolin-PRMT5 complex from the nucleus to the cytoplasm.
AS1411 inhibits IKK activity and reduces phosphorylation of IkappaBalpha in response to tumor necrosis factor-alpha stimulation.
AS1411 blocks both tumor necrosis factor-alpha-induced and constitutive NF-kappaB activity in human cancer cell lines derived from cervical, prostate, breast, and lung carcinomas.

Physicochemical Properties

M.Wt 8272.31
Formula C260H322N103O163P25
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

References

1. Girvan AC, et al. Mol Cancer Ther. 2006 Jul;5(7):1790-9.

2. Teng Y, et al. Cancer Res. 2007 Nov 1;67(21):10491-500.

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