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Chemical Structure : AS1949490
CAS No.: 1203680-76-5
Catalog No.: PC-70136Not For Human Use, Lab Use Only.
AS-1949490 (AS1949490) is a potent, selective SHIP2 inhibitor with IC50 of 0.34/0.62 uM for mouse/human SHIP2.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $118 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $288 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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AS1949490 (AS 1949490) is a potent, selective SHIP2 inhibitor with IC50 of 0.34/0.62 uM for mouse/human SHIP2.
AS1949490 displays 30-fold selectivity over SHIP1, and other intracellular phosphatases.
AS1949490 increases the phosphorylation of Akt, glucose consumption and glucose uptake in L6 myotubes and suppresses gluconeogenesis in FAO hepatocytes.
| M.Wt | 371.88 | |
| Formula | C20H18ClNO2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
3-[(4-Chlorophenyl)methoxy]-N-[(1S)-1-phenylethyl]-2-thiophenecarboxamide |
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1. Suwa A, et al. Br J Pharmacol. 2009 Oct;158(3):879-87.
2. Ichihara Y, et al. Eur J Med Chem. 2013 Apr;62:649-60.
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