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AS1949490

Chemical Structure : AS1949490

CAS No.: 1203680-76-5

AS1949490 (AS 1949490;AS-1949490)

Catalog No.: PC-70136Not For Human Use, Lab Use Only.

AS-1949490 (AS1949490) is a potent, selective SHIP2 inhibitor with IC50 of 0.34/0.62 uM for mouse/human SHIP2.

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10 mg $188 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AS1949490 (AS 1949490) is a potent, selective SHIP2 inhibitor with IC50 of 0.34/0.62 uM for mouse/human SHIP2.
AS1949490 displays 30-fold selectivity over SHIP1, and other intracellular phosphatases.
AS1949490 increases the phosphorylation of Akt, glucose consumption and glucose uptake in L6 myotubes and suppresses gluconeogenesis in FAO hepatocytes.

Physicochemical Properties

M.Wt 371.88
Formula C20H18ClNO2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-[(4-Chlorophenyl)methoxy]-N-[(1S)-1-phenylethyl]-2-thiophenecarboxamide

References

1. Suwa A, et al. Br J Pharmacol. 2009 Oct;158(3):879-87.

2. Ichihara Y, et al. Eur J Med Chem. 2013 Apr;62:649-60.

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