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Chemical Structure : AS2795440
Catalog No.: PC-60992Not For Human Use, Lab Use Only.
AS2795440 is a potent, selective, oral PIKfyve inhibitor that selectively decreases c-Rel binding to gene promoters of IL-12p40 and IL-1β, regulates cytokine production through PIKfyve-c-Rel pathway ( IL-12p40 IC50=2 nM).
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AS2795440 is a potent, selective, oral PIKfyve inhibitor that selectively decreases c-Rel binding to gene promoters of IL-12p40 and IL-1β, regulates cytokine production through PIKfyve-c-Rel pathway ( IL-12p40 IC50=2 nM).
AS2795440 inhibits the production of IL-12p40, IL-6 and IL-1β but not TNFα in activated macrophages or dendritic cells, and expression of IgM-induced MHC class II on B cells.
AS2795440 reduces Akt phosphorylation in IFNγ/LPS-stimulated RAW264.7 cells.
AS2795440 greatly increases cell size with many small vesicles in the cytoplasm; prevents the development of arthritis in rats.
| M.Wt | 480.62 | |
| Formula | C29H32N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Terajima M, et al. Eur J Pharmacol. 2016 Jun 5;780:93-105.
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