Catalog No.: PC-62327Not For Human Use, Lab Use Only.
AS8351 (NS 51355) is a small molecule that induces reprogramming of human fetal lung fibroblasts into functional cardiomyocytes, in combination with CHIR 99021, A83-01, BIX 01294, SC1, Y-27632, OAC2, SU 16f and JNJ 10198409, inhibits lysine demethylase 5B (KDM5B).
AS8351 (AS-8351, NS 51355) is a small molecule that induces reprogramming of human fetal lung fibroblasts into functional cardiomyocytes, in combination with CHIR 99021, A83-01, BIX 01294, SC1, Y-27632, OAC2, SU 16f and JNJ 10198409, inhibits lysine demethylase 5B (KDM5B).
AS-8351 competes with α-ketoglutarate (α-KG) for chelating iron/Fe(II) in certain epi-genetic enzymes, such as the JmjC-domain-containing histone demethylases (JmjC-KDMs) that require α-KG and iron as co-factors.
Physicochemical Properties
M.Wt
291.31
Formula
C17H13N3O2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
2-Hydroxy-1-naphthaldehyde isonicotinoylhydrazone
References
1. Cao N, et al. Science. 2016 Jun 3;352(6290):1216-20.
