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Chemical Structure : AS8351
CAS No.: 796-42-9
Catalog No.: PC-62327Not For Human Use, Lab Use Only.
AS8351 (NS 51355) is a small molecule that induces reprogramming of human fetal lung fibroblasts into functional cardiomyocytes, in combination with CHIR 99021, A83-01, BIX 01294, SC1, Y-27632, OAC2, SU 16f and JNJ 10198409, inhibits lysine demethylase 5B (KDM5B).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $68 | In stock | |
| 25 mg | $118 | In stock | |
| 50 mg | $198 | In stock | |
| 100 mg | Get quote |
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AS8351 (NS 51355) is a small molecule that induces reprogramming of human fetal lung fibroblasts into functional cardiomyocytes, in combination with CHIR 99021, A83-01, BIX 01294, SC1, Y-27632, OAC2, SU 16f and JNJ 10198409, inhibits lysine demethylase 5B (KDM5B).
AS-8351 competes with α-ketoglutarate (α-KG) for chelating iron/Fe(II) in certain epi-genetic enzymes, such as the JmjC-domain-containing histone demethylases (JmjC-KDMs) that require α-KG and iron as co-factors.
| M.Wt | 291.31 | |
| Formula | C17H13N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2-Hydroxy-1-naphthaldehyde isonicotinoylhydrazone |
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1. Cao N, et al. Science. 2016 Jun 3;352(6290):1216-20.
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