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ASB17061

Chemical Structure : ASB17061

CAS No.: 1312993-33-1

ASB17061 (ASB-17061)

Catalog No.: PC-73065Not For Human Use, Lab Use Only.

ASB17061 (ASB-17061) is an orally active, selective chymase inhibitor with IC50 of 0.03 uM and 0.02 uM for mMCP-4 and human chymase, respecitvely.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ASB17061 (ASB-17061) is an orally active, selective chymase inhibitor with IC50 of 0.03 uM and 0.02 uM for mMCP-4 and human chymase, respecitvely.
    ASB17061 display little to no acitivites against bovine α-chymotrypsin, human cathepsin G, bovine trypsin and human elastase (all IC50> 1 uM).
    ASB17061 significantly suppressed angiotensin II-induced abdominal aortic aneurysm (AAA) formation in apolipoprotein E-deficient mice at 10 mg/kg/
    ASB17061 inhibited the accumulation of pro-MMP-9-producing cells in AAA lesions.

    Physicochemical Properties

    M.Wt 560.048
    Formula C27H34ClN5O6
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    2-amino-4-[(1 R)-1-({[(3Z, 6S)-6-(5-chloro-2-methoxybenzyl)-3-(ethoxyimino)-7-oxo-1,4-diazepan-1-yl]carbonyl}amino) butyl]benzoic acid

    References

    1. Tomimori Y, et al. Eur J Pharmacol. 2019 Aug 5;856:172403.

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