Catalog No.: PC-63126Not For Human Use, Lab Use Only.
ASN-002 (Gusacitinib, ASN002) is a novel and potent dual inhibitor of SYK/JAK kinases with IC50 of 5, 46, 4, 11 and 8 nM for SYK, JAK1, JAK2, JAK3 and TYK2, respectively, in biochemical assays.
ASN-002 (Gusacitinib, ASN002) is a novel and potent dual inhibitor of SYK/JAK kinases with IC50 of 5, 46, 4, 11 and 8 nM for SYK, JAK1, JAK2, JAK3 and TYK2, respectively, in biochemical assays.
ASN-002 strongly suppresses the SYK and JAK family kinase signaling pathways measured as pLAT and pSTAT levels, respectively.
ASN-002 showed anti-proliferative activity in a broad panel of human cancer cell lines.
ASN-002 exhibits significant efficacy in inhibiting tumor growth in a multiple myeloma (H929) xenograft model.
