| Cat. No. |
Product Name |
Information |
| PC-21064 |
RDN2150
ZAP-70 inhibitor
|
RDN2150 is a potent, selective and covalent ZAP-70 inhibitor with IC50 of 14.6 nM, shows no significant activity against Syk, covalently binds to the C346 residue of ZAP-70. |
| PC-20791 |
3-MB-PP1
ZAP-70 inhibitor
|
3-MB-PP1 is specific inhibitor of analogue-sensitive ZAP70 (ZAP-70(AS)), does not affect Lck or Tec kinase activity, specifically targets ZAP-70AS-dependent events. |
| PC-73445 |
Sovleplenib
Syk inhibitor
|
Sovleplenib (HMPL-523) is a highly potent, selective, orally available SYK inhibitor with IC50 of 25 nM, demonstrates anti-tumor activity in B cell lymphomas. |
| PC-73180 |
Entospletinib
Syk inhibitor
|
Entospletinib (GS-9973) is a potent, selective and orally bioavailable Syk kinase inhibitor with IC50 of 7.7 nM. |
| PC-72472 |
RDN009
ZAP-70 inhibitor
|
RDN009 (RDN-009) is a potent, selective, and covalent ZAP-70 kinase inhibitor with IC50 of 55 nM. |
| PC-38196 |
SRX3207
Syk/PI3K inhibitor
|
SRX3207 (SRX-3207) is a potent, orally active dual Syk/PI3K inhibitor with IC50 of 39.9/244/388 nM for Syk/PI3Kα/PI3Kδ, respectively. |
| PC-38018 |
ZAP 180013
Zap70 inhibitor
|
ZAP 180013 is a small molecule inhibitor of zeta-chain-associated protein kinase 70 (Zap70) with IC50 of 1.8 uM (fluorescence polarization assay). |
| PC-35689 |
GSK2646264
Syk inhibitor
|
GSK2646264 (GSK-2646264) is a potent, selective Spleen Tyrosine Kinase (Syk) inhibitor with pIC50 of 7.1, >300-fold selectivity over Autota B. |
| PC-63503 |
TAS05567
Syk inhibitor
|
TAS05567 (TAS-5567) is a novel potent, selective, orally available Spleen tyrosine kinase (Syk) inhibitor with IC50 of 0.37 nM. |
| PC-63376 |
GSK143
Syk inhibitor
|
GSK143 is a highly potent, selective, orally efficacious Syk inhibitor with pIC50 of 7.5, >600-fold selective over ZAP-70. |
| PC-43350 |
R788 disodium hexahydrate
Syk inhibitor
|
Fostamatinib (R788) is a prodrug of the active metabolite R406, which is a potent, ATP-competitive inhibitor of Syk kinase with Ki/IC50 of 30/41 nM. |
| PC-43349 |
Fostamatinib
Syk inhibitor
|
Fostamatinib (R788) is a prodrug of the active metabolite R406, which is a potent, ATP-competitive inhibitor of Syk kinase with Ki/IC50 of 30/41 nM. |
