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3-MB-PP1

Chemical Structure : 3-MB-PP1

CAS No.: 956025-83-5

3-MB-PP1 (ZAP-70 inhibitor 3-MB-PP1)

Catalog No.: PC-20791Not For Human Use, Lab Use Only.

3-MB-PP1 is specific inhibitor of analogue-sensitive ZAP70 (ZAP-70(AS)), does not affect Lck or Tec kinase activity, specifically targets ZAP-70AS-dependent events.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

3-MB-PP1 is specific inhibitor of analogue-sensitive ZAP70 (ZAP-70(AS)), does not affect Lck or Tec kinase activity, specifically targets ZAP-70AS-dependent events.
3-MB-PP1 selectively shows sensitivity against the cells expressing the ZAP-70AS alleles.
3-MB-PP1 treatment (6 uM) blocked TCR-mediated signaling in both ZAP-70AS1 and ZAP-70AS2 stably transfected cells, with only a negligible effect on ZAP-70WT cells.
3-MB-PP1 effectively blocked calcium responses, inhibited almost all NFAT-driven luciferase activity, suppressed superantigen-mediated IL-2 induction.

Physicochemical Properties

M.Wt 295.39
Formula C17H21N5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-(1,1-dimethylethyl)-3-[(3-methylphenyl)methyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine

References

1. Au-Yeung BB, et al. Nat Immunol. 2010 Dec;11(12):1085-92.

2. Levin SE, et al. J Biol Chem. 2008;283:15419–15430.

3. Nicole M L Wong, et al. ACS Synth Biol. 2018 Apr 20;7(4):969-977.

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