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PRT062607

Chemical Structure : PRT062607

CAS No.: 1370261-96-3

PRT062607 (BIIB057, P505-15, PRT-062607)

Catalog No.: PC-22081Not For Human Use, Lab Use Only.

PRT062607 (P505-15) is a potent, highly specific, orally bioavailable inhibitor of Syk kinase with IC50 of 1 nM, also potently inhibits both insect and human PINK with an IC50 in the 0.5-3 µM range in HeLa cells and dopaminergic neurons.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PRT062607 (P505-15) is a potent, highly specific, orally bioavailable inhibitor of Syk kinase with IC50 of 1 nM, also potently inhibits both insect and human PINK with an IC50 in the 0.5-3 µM range in HeLa cells and dopaminergic neurons.
PRT062607 displays 80-fold greater than its affinity for other kinases.
PRT062607 potently inhibit SYK- and BCR-dependent activation of normal B-cells.
PRT062607 successfully inhibits SYK-mediated B-cell receptor signaling and decreased cell viability in NHL and CLL.
PRT062607 prevents BCR-mediated splenomegaly and significantly inhibited NHL tumor growth in a xenograft model.

Physicochemical Properties

M.Wt 393.46
Formula C19H23N9O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-((3-(2H-1,2,3-triazol-2-yl)phenyl)amino)-2-(((1R,2S)-2-aminocyclohexyl)amino)pyrimidine-5-carboxamide

References

1. Spurgeon SE, et al. J Pharmacol Exp Ther. 2013 Feb;344(2):378-87.

2. Rasool S, et al. Sci Rep. 2024 Apr 2;14(1):7739.

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