Catalog No.: PC-22082Not For Human Use, Lab Use Only.
PRT062607 (P505-15) hydrochloride is a potent, highly specific, orally bioavailable inhibitor of Syk kinase with IC50 of 1 nM, also potently inhibits both insect and human PINK with an IC50 in the 0.5-3 µM range in HeLa cells and dopaminergic neurons.
PRT062607 (P505-15) hydrochloride is a potent, highly specific, orally bioavailable inhibitor of Syk kinase with IC50 of 1 nM, also potently inhibits both insect and human PINK with an IC50 in the 0.5-3 µM range in HeLa cells and dopaminergic neurons.
PRT062607 displays 80-fold greater than its affinity for other kinases.
PRT062607 potently inhibit SYK- and BCR-dependent activation of normal B-cells.
PRT062607 successfully inhibits SYK-mediated B-cell receptor signaling and decreased cell viability in NHL and CLL.
PRT062607 prevents BCR-mediated splenomegaly and significantly inhibited NHL tumor growth in a xenograft model.
