| Cat. No. |
Product Name |
Information |
| PC-61632 |
ER-27319 maleate
Syk inhibitor
|
ER-27319 maleate is a potent, selective inhibitor of antigen or anti-IgE-mediated degranulation of rodent and human mast cells by selective inhibition of FcɛRI-mediated activation of Syk. |
| PC-61380 |
Lanraplenib
Syk inhibitor
|
Lanraplenib (GS-9876, GS9876) is a potent, selective, orally active Syk kinase inhibitor with IC50 of 9.5 nM. |
| PC-61366 |
Cevidoplenib
Syk inhibitor
|
Cevidoplenib (SKI-O-592) is a potent, selective spleen tyrosine kinase (Syk) inhibitor with IC50 of 6.2 nM. |
| PC-70330 |
BI1002494 trifluoroacetate
Syk inhibitor
|
BI1002494 trifluoroacetate is a potent, and selective spleen tyrosine kinase (SYK) inhibitor with enzyme IC50 of 30 nM, cell IC50 of 7 nM (FcεR1-mediated histamine release in human monocyte-derived mast cells, in the presence of 0.1% albumin). |
| PC-70329 |
BI1002494
Syk inhibitor
|
BI1002494 (BI-1002494) is a novel, potent, and selective spleen tyrosine kinase (SYK) inhibitor with enzyme IC50 of 30 nM, cell IC50 of 7 nM (FcεR1-mediated histamine release in human monocyte-derived mast cells, in the presence of 0.1% albumin). |
| PC-70328 |
HXJ 42
ZAP-70 inhibitor
|
HXJ 42 is a PP1 analog that has greater selectivity and potency for Zap-70(AS) over wild-type Zap-70, as assessed by Erk and Lat phosphorylation, as well as by proliferative responses of mature CD4+ cells. |
| PC-60451 |
TAK-659 hydrochloride
SYK inhibitor
|
TAK-659 hydrochloride (Mivavotinib, TAK659) is a potent, selective and orally available SYK inhibitor with IC50 of 3.2 nM. |
| PC-60450 |
TAK-659
SYK inhibitor
|
TAK-659 (TAK659, Mivavotinib) is a potent, selective and orally available SYK inhibitor with IC50 of 3.2 nM. |
| PC-45992 |
MNS
Syk inhibitor
|
MNS is a potent, selective Src and Syk kinase inhibitor with IC50 of 29.3 uM and 2.5 uM, respectively. |
| PC-45970 |
BAY 61-3606
Syk inhibitor
|
BAY 61-3606 is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase with Ki of 7.5 nM, displays no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src. |
| PC-44143 |
BAY 61-3606 dihydrochloride
Syk inhibitor
|
BAY 61-3606 dihydrochloride is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase with Ki of 7.5 nM, displays no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src. |
| PC-43303 |
PRT-060318
SYK inhibitor
|
PRT-060318 is a potent and selective Syk inhibitor with IC50 of 4 nM. |
