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Chemical Structure : HXJ 42
Catalog No.: PC-70328Not For Human Use, Lab Use Only.
HXJ 42 is a PP1 analog that has greater selectivity and potency for Zap-70(AS) over wild-type Zap-70, as assessed by Erk and Lat phosphorylation, as well as by proliferative responses of mature CD4+ cells.
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HXJ 42 is a PP1 analog that has greater selectivity and potency for Zap-70(AS) over wild-type Zap-70, as assessed by Erk and Lat phosphorylation, as well as by proliferative responses of mature CD4+ cells.
HXJ 42 effectively rescues Zap70(AS) OT-I cells from negative selection.
| M.Wt | 352.219 | |
| Formula | C15H15Cl2N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Au-Yeung BB, et al. Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):E3679-88.
2. Au-Yeung BB, et al. Nat Immunol. 2014 Jul;15(7):687-94.
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