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HXJ 42

Chemical Structure : HXJ 42

CAS No.: 1428640-39-4

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HXJ 42 (HXJ42)

Catalog No.: PC-70328Not For Human Use, Lab Use Only.

HXJ 42 is a PP1 analog that has greater selectivity and potency for Zap-70(AS) over wild-type Zap-70, as assessed by Erk and Lat phosphorylation, as well as by proliferative responses of mature CD4+ cells.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

HXJ 42 is a PP1 analog that has greater selectivity and potency for Zap-70(AS) over wild-type Zap-70, as assessed by Erk and Lat phosphorylation, as well as by proliferative responses of mature CD4+ cells.
HXJ 42 effectively rescues Zap70(AS) OT-I cells from negative selection.

Physicochemical Properties

M.Wt 352.219
Formula C15H15Cl2N5O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)(2,3-dichlorophenyl)methanol

References

1. Au-Yeung BB, et al. Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):E3679-88.

2. Au-Yeung BB, et al. Nat Immunol. 2014 Jul;15(7):687-94.

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