HXJ42 | Zap-70(AS) inhibitor | Probechem Biochemicals

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Chemical Structure : HXJ42

HXJ42 (HXJ-42)

Catalog No.: PC-70328Not For Human Use, Lab Use Only.

HXJ42 is a PP1 analog that has greater selectivity and potency for Zap-70(AS) over wild-type Zap-70.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

HXJ42 is a PP1 analog that has greater selectivity and potency for Zap-70(AS) over wild-type Zap-70, as assessed by Erk and Lat phosphorylation, as well as by proliferative responses of mature CD4+ cells.
HXJ42 effectively rescues Zap70(AS) OT-I cells from negative selection.

Physicochemical Properties

M.Wt	352.219
Formula	C15H15Cl2N5O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)(2,3-dichlorophenyl)methanol

References

1. Au-Yeung BB, et al. Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):E3679-88.

2. Au-Yeung BB, et al. Nat Immunol. 2014 Jul;15(7):687-94.

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HXJ42 (HXJ-42)

Biological Activity

Physicochemical Properties

References

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