MNS is a potent, selective Src and Syk kinase inhibitor with IC50 of 29.3 uM and 2.5 uM, respectively.
MNS shows weak inhibitory effect on FAK and JAK2.
MNS potently prevents GPIIb/IIIa activation and platelet aggregation without directly affecting other signaling pathways required for platelet activation.
MNS also is a potent inhibitor for ATP-induced NLRP3 inflammasome activation, inhibits IL-1β secretion in LPS-primed mouse macrophages with IC50 of 2 uM.
Physicochemical Properties
M.Wt
193.1562
Formula
C9H7NO4
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
1,3-Benzodioxole, 5-(2-nitroethenyl)-
References
1. Wang WY, et al. Mol Pharmacol. 2006 Oct;70(4):1380-9.
2. He Y, et al. J Biol Chem. 2014 Jan 10;289(2):1142-50.
3. Wang WY, et al. Biochem Pharmacol. 2007 Aug 15;74(4):601-11.
