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Chemical Structure : MNS
CAS No.: 1485-00-3
Catalog No.: PC-45992Not For Human Use, Lab Use Only.
MNS is a potent, selective Src and Syk kinase inhibitor with IC50 of 29.3 uM and 2.5 uM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 100 mg | $48 | In stock | |
| 200 mg | $68 | In stock | |
| 500 mg | $98 | In stock | |
| 1 g | Get quote |
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MNS is a potent, selective Src and Syk kinase inhibitor with IC50 of 29.3 uM and 2.5 uM, respectively.
MNS shows weak inhibitory effect on FAK and JAK2.
MNS potently prevents GPIIb/IIIa activation and platelet aggregation without directly affecting other signaling pathways required for platelet activation.
MNS also is a potent inhibitor for ATP-induced NLRP3 inflammasome activation, inhibits IL-1β secretion in LPS-primed mouse macrophages with IC50 of 2 uM.
| M.Wt | 193.1562 | |
| Formula | C9H7NO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
1,3-Benzodioxole, 5-(2-nitroethenyl)- |
|
1. Wang WY, et al. Mol Pharmacol. 2006 Oct;70(4):1380-9.
2. He Y, et al. J Biol Chem. 2014 Jan 10;289(2):1142-50.
3. Wang WY, et al. Biochem Pharmacol. 2007 Aug 15;74(4):601-11.
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