Syk-IN-23 |CAS:2040321-29-5 Probechem Biochemicals

Chemical Structure : Syk-IN-23

Syk-IN-23

Catalog No.: PC-62789Not For Human Use, Lab Use Only.

Syk-IN-23 is a potent, selective Syk kinase inhibitor with IC50 of 20 nM, possesses good PK in both rat and dog and demonstrated efficacy in rat CIA model.

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Biological Activity

Syk-IN-23 is a potent, selective Syk kinase inhibitor with IC50 of 20 nM, possesses good PK in both rat and dog and demonstrated efficacy in rat CIA model.

Physicochemical Properties

M.Wt	474.469
Formula	C22H24F2N6O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl (R)-(8-((4-((2,2-difluoroethyl)amino)furo[3,2-d]pyrimidin-2-yl)amino)-5,5-dimethyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl)carbamate

References

1. Hoemann M, et al. Bioorg Med Chem Lett. 2016 Nov 15;26(22):5562-5567.

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Syk-IN-23

Biological Activity

Physicochemical Properties

References

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