BI1002494 trifluoroacetate
(BI 1002494 trifluoroacetate)
Catalog No.: PC-70330Not For Human Use, Lab Use Only.
BI1002494 trifluoroacetate is a potent, and selective spleen tyrosine kinase (SYK) inhibitor with enzyme IC50 of 30 nM, cell IC50 of 7 nM (FcεR1-mediated histamine release in human monocyte-derived mast cells, in the presence of 0.1% albumin).
BI1002494 trifluoroacetate is a potent, and selective spleen tyrosine kinase (SYK) inhibitor with enzyme IC50 of 30 nM, cell IC50 of 7 nM (FcεR1-mediated histamine release in human monocyte-derived mast cells, in the presence of 0.1% albumin).
BI1002494 inhibits high-affinity IgE receptor-mediated mast cell and basophil degranulation (IC50=115 nM), 7-fold lower potency for blocking CD69 expression after anti-IgD (BCR) stimulation of peripheral B cells.
BI1002494 dose-dependently inhibited OVA-induced bronchioalveolar lavage eosinophils in brown Norway rats.
