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Chemical Structure : TAK-659 hydrochloride
CAS No.: 1952251-28-3
Catalog No.: PC-60451Not For Human Use, Lab Use Only.
TAK-659 hydrochloride (Mivavotinib, TAK659) is a potent, selective and orally available SYK inhibitor with IC50 of 3.2 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 25 mg | $228 | In stock | |
| 100 mg | $598 | In stock | |
| 500 mg | Get quote |
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TAK-659 hydrochloride (Mivavotinib, TAK659) is a potent, selective and orally available SYK inhibitor with IC50 of 3.2 nM.
TAK-659 displays 36, 42 and 23-fold selectivity over JAK3, ZAP70 and VEGFR2, respectively.
TAK-659 also potently inhibits FLT-3; inhibits cellular proliferation in SYK-dependent DLBCL and FLT3-dependent AML cell lines, demonstrates potent tumor growth inhibition in the FLT3-dependent MV4-11 xenograft models.
| M.Wt | 380.852 | |
| Formula | C17H22ClFN6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
6-(((1R,2S)-2-aminocyclohexyl)amino)-7-fluoro-4-(1-methyl-1H-pyrazol-4-yl)-1,2-dihydro-3H-pyrrolo[3,4-c]pyridin-3-one hydrochloride |
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1. Lam B, et al. Bioorg Med Chem Lett. 2016 Dec 15;26(24):5947-5950.
2. Purroy N, et al. Oncotarget. 2017 Jan 3;8(1):742-756.
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