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Chemical Structure : TAK-659
Catalog No.: PC-60450Not For Human Use, Lab Use Only.
TAK-659 (TAK659, Mivavotinib) is a potent, selective and orally available SYK inhibitor with IC50 of 3.2 nM.
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TAK-659 (TAK659, Mivavotinib) is a potent, selective and orally available SYK inhibitor with IC50 of 3.2 nM.
TAK-659 displays 36, 42 and 23-fold selectivity over JAK3, ZAP70 and VEGFR2, respectively.
TAK-659 also potently inhibits FLT-3.
TAK-659 inhibits cellular proliferation in SYK-dependent DLBCL and FLT3-dependent AML cell lines, demonstrates potent tumor growth inhibition in the FLT3-dependent MV4-11 xenograft models.
| M.Wt | 344.394 | |
| Formula | C17H21FN6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lam B, et al. Bioorg Med Chem Lett. 2016 Dec 15;26(24):5947-5950.
2. Purroy N, et al. Oncotarget. 2017 Jan 3;8(1):742-756.
3. Liu D, et al. J Hematol Oncol. 2017 Jul 28;10(1):145.
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