Catalog No.: PC-49627Not For Human Use, Lab Use Only.
MTX-216 (MTX216) is a dual PI3K/EGFR inhibitor that blocks neurofibromin 1 loss of function (NF1LoF) melanoma cell growth in vitro and in vivo, suppresses the activity of SYK kinase with IC50 of 281 nM.
MTX-216 (MTX216) is a dual PI3K/EGFR inhibitor that blocks neurofibromin 1 loss of function (NF1LoF) melanoma cell growth in vitro and in vivo, suppresses the activity of SYK kinase with IC50 of 281 nM.
MTX-216 at 1 μmol/L inhibited p-SYK expression in MeWo cells by approximately 50%, reduced p-BLNK levels in IgM-stimulated Ramos cells.
MTX-216 increases NF1LoF melanoma cells sensitivity to both PI3K and MEK inhibitors, suppresses genes that regulate mitochondrial ETC in NF1LoF cells.
MTX-216 effectively suppressed both Ki-67 and p-S6 in NF1LoF melanoma cells, inducing efficacious antitumor responses in these cells.
