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Chemical Structure : RDN2150
CAS No.: 2839429-51-3
Catalog No.: PC-21064Not For Human Use, Lab Use Only.
RDN2150 is a potent, selective and covalent ZAP-70 inhibitor with IC50 of 14.6 nM, shows no significant activity against Syk, covalently binds to the C346 residue of ZAP-70.
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|---|---|---|---|
| 2 mg | $248 | In stock | |
| 5 mg | $398 | In stock | |
| 10 mg | $598 | In stock | |
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RDN2150 is a potent, selective and covalent ZAP-70 inhibitor with IC50 of 14.6 nM, shows no significant activity against Syk, covalently binds to the C346 residue of ZAP-70.
RDN2150 exhibits favorable selectivity on a 97-kinase selectivity profiling using the ScanEDGE KINOMEscan assay at 1 uM.
RDN2150 (400 nM, 48h) significantly decreases the frequency of CD69+/CD4+ T cells from 21.3 to 10.8% on CD4+ T cells stimulated by anti-CD3 plus anti-CD28 antibodies.
RDN2150 selectively inhibits CD4+ T cell activation, inhibits the secretion of IFN-γ and IL-17A in the culture supernatant of activated CD4+ T cells, effectively suppresses the phosphorylation of LAT induced by anti-CD3/CD28 stimulation.
RDN2150 ameliorates murine psoriatic skin lesions in the IMQ-induced psoriasis mouse model.
| M.Wt | 577.04 | |
| Formula | C28H29ClN8O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5-((3-acrylamido-4-chlorobenzyl)amino)-7-((3-methoxy-4-morpholinophenyl)amino)imidazo[1,2-c]pyrimidine-8-carboxamide |
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1. Danni Rao, et al. J Med Chem. 2023 Aug 18. doi: 10.1021/acs.jmedchem.3c00606.
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