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Chemical Structure : ASP5878
CAS No.: 1453208-66-6
Catalog No.: PC-70221Not For Human Use, Lab Use Only.
ASP-5878 (ASP5878) is a novel potent, selective pan-FGFR inhibitor with IC50 of 0.47/0.60/0.74/3.5 nM for FGFR1/2/3/4, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $198 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $498 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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ASP-5878 (ASP5878) is a novel potent, selective pan-FGFR inhibitor with IC50 of 0.47/0.60/0.74/3.5 nM for FGFR1/2/3/4, respectively.
ASP-5878 also inhibits FGFR3 (K650E), FGFR3 (K650M), VEGFR2, FGFR4 (N535K), FMS with IC50 of 1.6, 4.2, 25, 78, 150 nM, respectively.
ASP-5878 potently suppressed the growth of the FGF19-expressing hepatocellular carcinoma cell lines Hep3B2.1-7, HuH-7, and JHH-7 with IC50 of 8.5-27 nM.
ASP-5878 induces sustained tumor regression in a xenograft mouse model using Hep3B2.1-7. Orally bioactive.
| M.Wt | 407.378 | |
| Formula | C18H19F2N5O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 250 mg/mL |
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| Chemical Name/SMILES |
2-(4-((5-((2,6-difluoro-3,5-dimethoxybenzyl)oxy)pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)ethan-1-ol |
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1. Futami T, et al. Mol Cancer Ther. 2017 Jan;16(1):68-75.
2. Kikuchi A, et al. Cancer Sci. 2017 Feb;108(2):236-242.
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