| Cat. No. |
Product Name |
Information |
| PC-20046 |
RLY-4008
FGFR2 inhibitor
|
Lirafugratinib (RLY-4008, RYL4008) is a potent, highly selective and irreversible FGFR2 inhibitor with biochemical IC50 of <100 nM, shows high cellular potency (IC50=6 nM, pFGFR; pERK, IC50=3 nM). |
| PC-73227 |
CXF-009
FGFR4 inhibitor
|
CXF-009 is a potent, specific, dual-warhead covalent inhibitor of FGFR4 (IC50=48 nM), forms dual-warhead covalent bonds with two cysteine residues in FGFR4. |
| PC-35715 |
ODM-203
FGFR inhibitor
|
ODM-203 (ODM203) is a potent, selective, dual inhibitor of FGFR and VEGFR tyrosine kinases with approximately equal potency towards recombinant FGFR1, 2, 3 and 4, as well as VEGFR1, 2 and 3 (IC50=5-35 nM). |
| PC-35453 |
TAS-120
FGFR inhibitor
|
TAS-120 (Futibatinib, TAS120) is a highly potent, selective, irreversible pan-FGFR inhibitor with IC50 of 0.9 nM for wt FGFR2. |
| PC-35144 |
E7090
FGFR inhibitor
|
E7090 (Tasurgratinib) is a potent, selective, orally available inhibitor of FGFR1, -2, and -3 with IC50 of 0.71, 0.50 and 1.2 nM, weakly inhibits FGFR4 (IC50=120 nM). |
| PC-43484 |
Infigratinib
FGFR inhibitor
|
Infigratinib (NVP-BGJ398, BGJ398) is a potent, selective pan-FGFR inhibitor with IC50 of 0.9/1.0/1.4/60 nM for FGFR1/2/3/4, also shows high potenct against mutant FGFR3-K650E with IC50 of 4.9 nM. |
| PC-43480 |
LY2874455
FGFR inhibitor
|
LY2874455 is a potent, selective pan-FGFR inhibitor with IC50 of 2.8/2.6/6.4/6 nM for FGFR1/2/3/4, respectively. |
| PC-43232 |
BLU9931
FGFR4 inhibitor
|
BLU9931 (BLU-9931) is a potent, selective, irreversible inhibitor of FGFR4 with IC50 of 3 nM, shows much weaker activity for FGFR1 (IC50=591 nM), FGFR2 (IC50=493 nM) and FGFR3 (IC50=150 nM). |
| PC-61963 |
Rogaratinib
|
Rogaratinib (BAY 1163877) is a potent, selective, orally available pan-FGFR with IC50 of 15, <1, 19 and 33 nM for FGFR1, 2, 3 and 4, respectively. |
| PC-61394 |
Pemigatinib
FGFR inhibitor
|
Pemigatinib (INCB054828, INCB 054828) is a potent, selective, orally bioavailable inhibitor of FGFR1/2/3 with IC50 of 0.4 nM, 0.5 nM, 1.2 nM and 30 nM for FGFR1/2/3/4, respectively. |
| PC-60784 |
H3B-6527
|
H3B-6527 is a potent, highly selective covalent FGFR4 inhibitor with IC50 of <1.2 nM, 250-fold selectivity over FGFR1-3 (IC50=320, 1290 and 1060 nM, respectively). |
| PC-60557 |
Alofanib
|
Alofanib ((RPT-835, ES 000835) is a potent, selective, allosteric FGFR2 inhibitor that significantly inhibits bFGF-induced proliferation of HUVEC cells with IC50 of 11 nM. |
