| Cat. No. |
Product Name |
Information |
| PC-24953 |
HMPL-453
FGFR1/2/3 inhibitor
|
HMPL-453 (Fanregratinib) is a potent, highly selective inhibitor of fibroblast growth factor receptors 1, 2, and 3 (FGFR1/2/3) with IC50 of 6, 4, and 6 nM, respectively, shows weaker activity against FGFR4 (IC50=425 nM). |
| PC-24894 |
INCB126503
FGFR2/3 inhibitor
|
INCB126503 is a highly potent, selective, orally bioavailable FGFR2/3 inhibitor with IC50 of 2.1/1.2 nM respectively. |
| PC-24856 |
ISM7594
FGFR2/3 inhibitor
|
ISM7594 is a potent, selective and covalent FGFR2/3 inhibitor with IC50 of 1.4/12.7 nM respectively, inhibits FGFR2 mutants and FGFR3 mutants with IC50 of 0.22-5.9 nM and 3.7-26 nM, selectively spares FGFR1/4. |
| PC-24068 |
BW710
FGFR2 inhibitor
|
BW710 is a potent, selective, covalent and orally bioavailable FGFR2 inhibitor, potently inhibits the proliferation of BaF3-FGFR2 cells with IC50 of 2.8 nM. |
| PC-23839 |
TYRA-300
FGFR3 inhibitor
|
Dabogratinib (TYRA-300) is a potent, selective and oral FGFR3 inhibitor with IC50 of 11 nM in in Ba/F3 cells, 14-fold seletive over FGFR2 and >20-fold over FGFR1, FGFR4. |
| PC-22684 |
SSR128129E
FGFR inhibitor
|
SSR128129E is a specific, allosteric, small-molecule multi-FGF receptor (FGFR) inhibitor, binds to the extracellular FGFR domain without affecting orthosteric FGF binding. |
| PC-22316 |
LHQ490
FGFR2 inhibitor
|
LHQ490 is a potent, highly selective fibroblast growth factor receptor 2 (FGFR2) inhibitor with Ic50 of 5.2 nM, >61-, >34-, and >293-fold selective against FGFR1, FGFR3, and FGFR4. |
| PC-21612 |
DW14383
FGFR inhibitor
|
DW14383 is a potent, selective and irreversible inhibitor of FGFR1-4 with IC50 of <0.3 nM, 1.1 nM, <0.3 nM and 0.5 nM for FGFR1/2/3/4 respectively. |
| PC-21538 |
ABSK011
FGFR4 inhibitor
|
Irpagratinib (ABSK011) is a potent, selective FGFR4 inhibitor with strong antitumor activity against hepatocellular carcinoma (HCC). |
| PC-21321 |
KIN-3248
FGFR inhibitor
|
Resigratinib (KIN-3248) is a next-generation, irreversible, orally available, small molecule pan-FGFR inhibitor with IC50 of 3.9/5.3/9.7 nM for FGFR1/2/3, potently inhibits FGFR2 and FGFR3 gatekeeper, molecular brake, and activation loop mutations with IC50 of 5-20 nM. |
| PC-20046 |
RLY-4008
FGFR2 inhibitor
|
Lirafugratinib (RLY-4008, RYL4008) is a potent, highly selective and irreversible FGFR2 inhibitor with biochemical IC50 of <100 nM, shows high cellular potency (IC50=6 nM, pFGFR; pERK, IC50=3 nM). |
| PC-49580 |
FRS2 ligand 7
FRS2 inhibitor
|
FRS2 ligand 7 is a small molecule ligand of the PTB domain of FGFR proximal adaptor protein FRS2, prevents FRS2 activation and interrupts FGFR signaling, inhibits invasion and tumor growth. |
