| Cat. No. |
Product Name |
Information |
| PC-42352 |
PD-166866
FGFR1 inhibitor
|
PD-166866 is a potent, selective, ATP competitive FGFR1 inhibitor with IC50 of 52.4 nM, has no effect on c-Src, PDGFR-β, EGFR or InsR tyrosine kinases or on MEK, PKC and CDK4 (IC50>50 uM). |
| PC-61963 |
Rogaratinib
FGFR inhibitor
|
Rogaratinib (BAY 1163877) is a potent, selective, orally available pan-FGFR with IC50 of 15, <1, 19 and 33 nM for FGFR1, 2, 3 and 4, respectively. |
| PC-61394 |
Pemigatinib
FGFR inhibitor
|
Pemigatinib (INCB054828, INCB 054828) is a potent, selective, orally bioavailable inhibitor of FGFR1/2/3 with IC50 of 0.4 nM, 0.5 nM, 1.2 nM and 30 nM for FGFR1/2/3/4, respectively. |
| PC-60784 |
H3B-6527
FGFR4 inhibitor
|
H3B-6527 is a potent, highly selective covalent FGFR4 inhibitor with IC50 of <1.2 nM, 250-fold selectivity over FGFR1-3 (IC50=320, 1290 and 1060 nM, respectively). |
| PC-60557 |
Alofanib
FGFR2 inhibitor
|
Alofanib ((RPT-835, ES 000835) is a potent, selective, allosteric FGFR2 inhibitor that significantly inhibits bFGF-induced proliferation of HUVEC cells with IC50 of 11 nM. |
| PC-70221 |
ASP5878
FGFR inhibitor
|
ASP-5878 (ASP5878) is a novel potent, selective pan-FGFR inhibitor with IC50 of 0.47/0.60/0.74/3.5 nM for FGFR1/2/3/4, respectively. |
| PC-60465 |
MPT0L145
PIK3C3/FGFR inhibitor
|
MPT0L145 is a nove potent, dual FGFR and PIK3C3 inhibitor with Kd of 0.53 nM for PIK3C3. |
| PC-60073 |
PRN-1371
FGFR inhibitor
|
PRN-1371 (PRN1371) is a potent, selective, irreversible covalent, orally active pan-FGFR inhibitor with IC50 of 0.6/1.3/4.1/19.3 nM for FGFR1/2/3/4, respectively. |
| PC-60038 |
Derazantinib
FGFR inhibitor
|
Derazantinib (ARQ-087) is a novel potent, ATP competitive multi-kinase inhibitor with IC50 of FGFR1/2/3 with IC50 of 1.8-4.5 nM. |
| PC-45474 |
FIIN-2
FGFR inhibitor
|
FIIN-2 is a potent, irreversible inhibitor of FGFR with IC50 values of 3.1/ 4.3/27/45 nM for FGFR1/2/3/4. |
| PC-42521 |
PD173074
FGFR1 inhibitor
|
PD173074 is a potent, selective, ATP-competitive FGFR1 inhibitor with IC50 of ~25 nM. |
| PC-45761 |
Zoligratinib
FGFR inhibitor
|
CH-5183284 (Debio-1347, Debio1347) is a potent, selective and orally available FGFR1/2/3 inhibitor with enzyme IC50 of 9.3/7.6/22 nM, respectively. |
