| Cat. No. |
Product Name |
Information |
| PC-49450 |
FGFR2/3 inhibitor 29
FGFR2/3 inhibitor
|
FGFR2/3 inhibitor 29 is a potent and selective inhibitor of FGFR2/3 wild-type and gatekeeper mutant with IC50 of 1 nM and 0.5 nM for FGFR2 and FGFR3, respectively. |
| PC-38509 |
PD089828
FGFR inhibitor
|
PD089828 is an ATP competitive inhibitor of FGFR-1, PDGFR-β and EGFR with IC50 of 0.15 uM, 1.76 uM, and 5.47 uM, respectively. |
| PC-38477 |
Alphastatin-C
bFGF inhibitor
|
Alphastatin-C is a 14-amino acids peptide consisting of a C-terminal fragment of the α-chain of Fgn, is a potent inhibitor of bFGF induced endothelial cell (HUVEC-CS) activation in vitro. |
| PC-38396 |
Gunagratinib
FGFR inhibitor
|
ICP-192 (Gunagratinib) is a novel potent, covalent pan-FGFR (fibroblast growth factor receptors) inhibitor, potently and selectively inhibits FGFR activities irreversibly by covalent binding. |
| PC-73227 |
CXF-009
FGFR4 inhibitor
|
CXF-009 is a potent, specific, dual-warhead covalent inhibitor of FGFR4 (IC50=48 nM), forms dual-warhead covalent bonds with two cysteine residues in FGFR4. |
| PC-72411 |
MAX-40279
FLT3/FGFR inhibitor
|
MAX-40279 (MAX40279, EX-A4057) is a dual inhibitor of FLT3 and FGFR for the treatment of Acute Myeloid Leukemia (AML). |
| PC-72310 |
FGFR4-IN-2
FGFR2 inhibitor
|
FGFR4-IN-2 is a potent, selective, covalent FGFR4 inhibitor with cellualr IC50 of 8.8 nM, 100-fold selectivity over FGFR2. |
| PC-72306 |
FGFR2 inhibitor 38
FGFR2 inhibitor
|
FGFR2 inhibitor 38 is a potent, selective FGFR2 inhibitor with IC50 of 29 nM, exhibits moderate selectivity for FGFR2 over FGFR1/3 (>13.4 fold). |
| PC-72218 |
CPL304110
FGFR inhibitor
|
CPL304110 (CPL-304110) is a selective and potent pan-FGFR inhibitor with IC50 of 0.75 nM, 0.50 nM, 3.05 nM against FGFR1, 2, 3, shows weaken acitvity against FGFR4 with IC50 of 87.9 nM. |
| PC-35715 |
ODM-203
FGFR inhibitor
|
ODM-203 (ODM203) is a potent, selective, dual inhibitor of FGFR and VEGFR tyrosine kinases with approximately equal potency towards recombinant FGFR1, 2, 3 and 4, as well as VEGFR1, 2 and 3 (IC50=5-35 nM). |
| PC-35453 |
Futibatinib
FGFR inhibitor
|
Futibatinib (TAS-120, TAS120) is a highly potent, selective, irreversible pan-FGFR inhibitor with IC50 of 0.9 nM for wt FGFR2. |
| PC-35145 |
E7090 succinate
FGFR inhibitor
|
E7090 (E 7090) is a potent, selective, orally available inhibitor of FGFR1, -2, and -3 with IC50 of 0.71, 0.50 and 1.2 nM, weakly inhibits FGFR4 (IC50=120 nM). |
