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Chemical Structure : LY2874455
CAS No.: 1254473-64-7
Catalog No.: PC-43480Not For Human Use, Lab Use Only.
LY2874455 is a potent, selective pan-FGFR inhibitor with IC50 of 2.8/2.6/6.4/6 nM for FGFR1/2/3/4, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $188 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | $428 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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LY2874455 is a potent, selective pan-FGFR inhibitor with IC50 of 2.8/2.6/6.4/6 nM for FGFR1/2/3/4, respectively.
LY2874455 inhibits FGFR2 phosphorylation in SNU-16 and KATO-III cells with IC50 of 0.8 and1.5 nM, also inhibits the phosphorylation of FRS2, an immediate downstream target of FGFR, with a similar potency of 0.8 to 1.5 nM.
LY2874455 exhibits a potent activity against FGF/FGFR-mediated signaling in several cancer cell lines and shows an excellent broad spectrum of antitumor activity in several tumor xenograft models representing the major FGF/FGFR relevant tumor histologies including lung, gastric, and bladder cancers and multiple myeloma.
| M.Wt | 444.31 | |
| Formula | C21H19Cl2N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1H-Pyrazole-1-ethanol, 4-[(1E)-2-[5-[(1R)-1-(3,5-dichloro-4-pyridinyl)ethoxy]-1H-indazol-3-yl]ethenyl]- |
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1. Zhao G, et al. Mol Cancer Ther. 2011 Nov;10(11):2200-10.
2. Kim SY, et al. Oncotarget. 2017 Feb 28;8(9):15014-15022.
3. Michael M, et al. Target Oncol. 2017 Aug;12(4):463-474.
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