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Chemical Structure : ODM-203
CAS No.: 1430723-35-5
Catalog No.: PC-35715Not For Human Use, Lab Use Only.
ODM-203 (ODM203) is a potent, selective, dual inhibitor of FGFR and VEGFR tyrosine kinases with approximately equal potency towards recombinant FGFR1, 2, 3 and 4, as well as VEGFR1, 2 and 3 (IC50=5-35 nM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $158 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $458 | In stock | |
| 100 mg | $798 | In stock | |
| 500 mg | Get quote | ||
| 1 g | Get quote |
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ODM-203 (ODM203) is a potent, selective, dual inhibitor of FGFR and VEGFR tyrosine kinases with approximately equal potency towards recombinant FGFR1, 2, 3 and 4, as well as VEGFR1, 2 and 3 (IC50=5-35 nM).
ODM-203 suppresses 9/317 additional kinases by >70% at 1 uM, 9 kinases suppressed by ODM-203 - DDR1, MAP4K4, MINK1, RET, PDGFRa and SIK2 (IC50<100 nM).
ODM-203 is a potent inhibitor of FGFR signaling and proliferation in several FGFR-dependent cell lines; ODM-203 inhibits VEGFR-induced tube formation (IC50 33 nM) with similar potency as it inhibits proliferation in FGFR-dependent cell lines (IC50 50-150 nM).
ODM-203 inhibits FGFR phosphorylation and tumor growth in several FGFR-dependent xenografts.
| M.Wt | 505.544 | |
| Formula | C26H21F2N5O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
100 mM in DMSO (50.5 mg/mL） |
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| Chemical Name/SMILES |
N-(2',4'-difluoro-5-(5-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-[1,1'-biphenyl]-3-yl)cyclopropanesulfonamide |
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1. Holmström TH, et al. Mol Cancer Ther. 2018 Oct 9. pii: molcanther.0204.2018.
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