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Chemical Structure : BLU9931
CAS No.: 1538604-68-0
Catalog No.: PC-43232Not For Human Use, Lab Use Only.
BLU9931 (BLU-9931) is a potent, selective, irreversible inhibitor of FGFR4 with IC50 of 3 nM, shows much weaker activity for FGFR1 (IC50=591 nM), FGFR2 (IC50=493 nM) and FGFR3 (IC50=150 nM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $158 | In stock | |
| 25 mg | $268 | In stock | |
| 50 mg | $428 | In stock | |
| 100 mg | Get quote |
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BLU9931 (BLU-9931) is a potent, selective, irreversible inhibitor of FGFR4 with IC50 of 3 nM.
BLU9931 shows much weaker activity for FGFR1 (IC50=591 nM), FGFR2 (IC50=493 nM) and FGFR3 (IC50=150 nM).
BLU9931 potently and selectively inhibits FGFR4 signaling and cell proliferation in HCC cell lines with an activated FGFR4 signaling pathway (Huh-7 cell IC50=110 nM, JHH-7 IC50=20 nM).
BLU9931 shows remarkable antitumor activity in mice bearing HCC tumor xenograft that overexpresses FGF19.
| M.Wt | 509.3839 | |
| Formula | C26H22Cl2N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 17 mg/mL |
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| Chemical Name/SMILES |
2-Propenamide, N-[2-[[6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-quinazolinyl]amino]-3-methylphenyl]- |
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1. Hagel M, et al. Cancer Discov. 2015 Apr;5(4):424-37.
2. Packer LM, et al. Cancer Discov. 2015 Apr;5(4):355-7.
3. Yamamoto M, et al. Cancer Sci. 2018 Mar 13. doi: 10.1111/cas.13569.
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