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Chemical Structure : FGFR4-IN-2
Catalog No.: PC-72310Not For Human Use, Lab Use Only.
FGFR4-IN-2 is a potent, selective, covalent FGFR4 inhibitor with cellualr IC50 of 8.8 nM, 100-fold selectivity over FGFR2.
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FGFR4-IN-2 is a potent, selective, covalent FGFR4 inhibitor with cellualr IC50 of 8.8 nM, 100-fold selectivity over FGFR2.
FGFR4-IN-2 potently and selectively inhibit FGFR4 signaling through covalent modification of Cys552.
FGFR4-IN-2 induces tumor regression in preclinical models of orthotopic and sorafenib-resistant HCC.
| M.Wt | 520.367 | |
| Formula | C23H23Cl2N5O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Haibo Liu, et al. ACS Med Chem Lett. 2020 Mar 6;11(10):1899-1904.
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