| Cat. No. |
Product Name |
Information |
| PC-72310 |
FGFR4-IN-2
FGFR2 inhibitor
|
FGFR4-IN-2 is a potent, selective, covalent FGFR4 inhibitor with cellualr IC50 of 8.8 nM, 100-fold selectivity over FGFR2. |
| PC-72306 |
FGFR2 inhibitor 38
FGFR2 inhibitor
|
FGFR2 inhibitor 38 is a potent, selective FGFR2 inhibitor with IC50 of 29 nM, exhibits moderate selectivity for FGFR2 over FGFR1/3 (>13.4 fold). |
| PC-35145 |
E7090 succinate
|
E7090 (E 7090) is a potent, selective, orally available inhibitor of FGFR1, -2, and -3 with IC50 of 0.71, 0.50 and 1.2 nM, weakly inhibits FGFR4 (IC50=120 nM). |
| PC-43485 |
NVP-BGJ398 phosphate
|
NVP-BGJ398 phosphate (Infigratinib phosphate, BGJ398 phosphate) is a potent, selective pan-FGFR inhibitor with IC50 of 0.9/1.0/1.4/60 nM for FGFR1/2/3/4, also shows high potenct against mutant FGFR3-K650E with IC50 of 4.9 nM. |
| PC-60628 |
NSC12
|
An orally active small-molecule chemical that acts as an extracellular FGF trap, binds immobilized FGF3,FGF4, FGF6, FGF8, FGF16, FGF18, FGF20, and FGF22 with Kd of 16-120 uM, inhibits FGF-dependent tumor growth, angiogenesis and metastases. |
| PC-45475 |
FIIN-3
|
A selective, next-generation, covalent dual FGFR/EGFR inhibitor (IC50=1-60 nM). |
| PC-42567 |
SU 5402
|
A selective FGFR1 inhibitor with IC50 of 10-20 uM. |
| PC-42217 |
FGFR4-IN-1
|
A potent, selective inhibiotr of FGFR4 with IC50 of 0.7 nM, significantly inhibits the proliferation of HuH-7 cells with IC50 of 7.8 nM.. |
| PC-42452 |
Dovitinib lactate
|
A novel, multitargeted RTK inhibitor of class III, IV, and V RTKs with IC50 of 1/2/36/8/9 nM for FLT3/c-KIT/c-Fms/FGFR1/FGFR3, respectively. |
| PC-42401 |
SUN11602
|
A novel aniline compound that mimics the neuroprotective effects of bFGF by activating FGFR1-MEK/ERK signaling pathway. |
