Chemical Structure : FGF-401
CAS No.:
1708971-55-4
FGF-401
(NVP-FGF401;Roblitinib;FGF401)
Catalog No. : PC-42406Not For Human Use, Lab Use Only.
FGF-401 (NVP-FGF401, Roblitinib, FGF401) is a first-in-class, potent, highly selective FGFR4 inhibitor with IC50 of 1.1 nM.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-4240601
Biological Activity
FGF-401 (NVP-FGF401, Roblitinib, FGF401) is a first-in-class, potent, highly selective FGFR4 inhibitor with IC50 of 1.1 nM.
Physicochemical Properties
M.Wt
506.567
Formula
C25H30N8O4
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
DMSO: 6 mg/mL (Need Ultrasonic)
Chemical Name/SMILES
1,8-Naphthyridine-1(2H)-carboxamide, N-[5-cyano-4-[(2-methoxyethyl)amino]-2-pyridinyl]-7-formyl-3,4-dihydro-6-[(4-methyl-2-oxo-1-piperazinyl)methyl]-
References
1. Diana Graus Porta, et al. Abstract 2098: NVP-FGF401, a first-in-class highly selective and potent FGFR4 inhibitor for the treatment of HCC, AACR
2. Patent
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