Catalog No.: PC-24068Not For Human Use, Lab Use Only.
BW710 is a potent, selective, covalent and orally bioavailable FGFR2 inhibitor, potently inhibits the proliferation of BaF3-FGFR2 cells with IC50 of 2.8 nM.
BW710 is a potent, selective, covalent and orally bioavailable FGFR2 inhibitor, potently inhibits the proliferation of BaF3-FGFR2 cells with IC50 of 2.8 nM.
BW710 covalently binds to FGFR2 kinase P-loop residue Cys491.
BW710 is much less active against BaF3-FGFR1 and parental BaF3 cells with IC50 values of >1000 nM.
BW710 completely abolished FGFR2 enzymatic activity and was selective against other 75 tyrosine kinases including FGFR1, FGFR3, and FGFR4 at 1 μM.
BW710 potently suppressed the FGFR2 signaling and selectively inhibited FGFR2-driven cancer cell proliferation.
