Chemical Structure : BW710
CAS No.:
BW710
(BW-710)
Catalog No.: PC-24068Not For Human Use, Lab Use Only.
BW710 is a potent, selective, covalent and orally bioavailable FGFR2 inhibitor, potently inhibits the proliferation of BaF3-FGFR2 cells with IC50 of 2.8 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
BW710 is a potent, selective, covalent and orally bioavailable FGFR2 inhibitor, potently inhibits the proliferation of BaF3-FGFR2 cells with IC50 of 2.8 nM.
BW710 covalently binds to FGFR2 kinase P-loop residue Cys491.
BW710 is much less active against BaF3-FGFR1 and parental BaF3 cells with IC50 values of >1000 nM.
BW710 completely abolished FGFR2 enzymatic activity and was selective against other 75 tyrosine kinases including FGFR1, FGFR3, and FGFR4 at 1 μM.
BW710 potently suppressed the FGFR2 signaling and selectively inhibited FGFR2-driven cancer cell proliferation.
Physicochemical Properties
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M.Wt
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532.64
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Formula
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C28H29FN6O2S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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NC1=C2C(N(C)C(C3=C(F)C=C(NC(C(C)=C)=O)C=C3)=C2C4=CC=C(S5(CCCCCN=5)=O)C=C4)=NC=N1
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References
1. Bowen Yang, et al. Eur J Med Chem. 2025 Feb 1:287:117339.
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