SUN11602 is an aniline compound that mimics the neuroprotective effects of bFGF by activating FGFR1-MEK/ERK signaling pathway.
SUN11602 prevents glutamate-induced neuronal death in primary cultures of rat cerebrocortical neurons, augments phosphorylation of FGFR-1 and ERK-1/2, increases the levels of CALB1 gene expression.
SUN11602 increases the levels of newly synthesized calcium-binding protein calbindin-D28k (Calb) in cerebrocortical neurons and suppresses the glutamate-induced rise in intracellular Ca(2+) in WT mice.
SUN11602 attenuates neuronal damage and cognitive deficits in a rat model of Alzheimer's disease.
