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Chemical Structure : Erdafitinib
CAS No.: 1346242-81-6
Catalog No.: PC-45537Not For Human Use, Lab Use Only.
Erdafitinib (JNJ-42756493) is a highly potent and selective, small-molecule inhibitor of FGFR family with IC50s of 1.2/2.5/3/5.7 nM for FGFR1/2/3/4.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | $598 | In stock | |
| 250 mg | Get quote | ||
| 1 g | Get quote |
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Erdafitinib (JNJ-42756493) is a highly potent and selective, small-molecule inhibitor of FGFR family with IC50s of 1.2/2.5/3/5.7 nM for FGFR1/2/3/4.
Erdafitinib (JNJ-42756493) shows rapid uptake into the lysosomal compartment of cells in culture, which is associated with prolonged inhibition of FGFR signaling; orally active.
| M.Wt | 446.5447 | |
| Formula | C25H30N6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 33 mg/mL |
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| Chemical Name/SMILES |
1,2-Ethanediamine, N1-(3,5-dimethoxyphenyl)-N2-(1-methylethyl)-N1-[3-(1-methyl-1H-pyrazol-4-yl)-6-quinoxalinyl]- |
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1. Perera TPS, et al. Mol Cancer Ther. 2017 Jun;16(6):1010-1020.
2. Karkera JD, et al. Mol Cancer Ther. 2017 Apr 17. pii: molcanther.0518.2016.
3. Verstraete M, et al. BMC Cancer. 2015 Dec 16;15:946.
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