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Chemical Structure : AZD4547
CAS No.: 1035270-39-3
Catalog No.: PC-43499Not For Human Use, Lab Use Only.
Fexagratinib (AZD4547, ADSK091) is a potent and selective inhibitor of FGFR1/2/3 with IC50s of 0.2/1.8/2.5 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 50 mg | $228 | In stock | |
| 100 mg | $378 | In stock | |
| 250 mg | $578 | In stock | |
| 1 g | Get quote |
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Fexagratinib (AZD4547, ADSK091) is a potent and selective inhibitor of FGFR1/2/3 with IC50s of 0.2/1.8/2.5 nM, respectively.
AZD4547 shows weak acticity against KDR(IC50=24 nM), FGFR4 (IC50=165 nM) and IGFR (IC50=581 nM), and on activity against CDK2, Axl, FAK, p38 etc.
AZD4547 suppresses FGFR signaling and growth in tumor cell lines with deregulated FGFR expression.
AZD4547 is orally bioavailable.
| M.Wt | 463.5719 | |
| Formula | C26H33N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Benzamide, N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-4-[(3R,5S)-3,5-dimethyl-1-piperazinyl]-, rel- |
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1. Gavine PR, et al. Cancer Res. 2012 Apr 15;72(8):2045-56.
2. Zhang J, et al. Clin Cancer Res. 2012 Dec 15;18(24):6658-67.
3. Kwak Y, et al. Mol Cancer Ther. 2015 Oct;14(10):2292-302.
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