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Chemical Structure : FGF trap compound 57
Catalog No.: PC-22625Not For Human Use, Lab Use Only.
FGF trap compound 57 is a non-steroidal NSC12 derivative as FGF trap small molecule, shows anti-myeloma activity.
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FGF trap compound 57 is a non-steroidal NSC12 derivative as FGF trap small molecule, shows anti-myeloma activity.
FGF trap compound 57 potently inhibits FGFR3 phosphorylation in KMS-11 cells about 74% at 6 uM.
FGF trap compound 57 significantly inhibited the formation of HSPG/FGF2/FGFR1 ternary complexes with a potency higher than NSC12 (Cat#PC-60628).
FGF trap compound 57 is able to hamper FGFR activation in FGFR1-overexpressing CHO cells stimulated with FGF2, significantly inhibits FGFR1 phosphorylation.
FGF trap compound 57 strongly reduced the levels of FGFR phosphorylation in MM cell lines.
FGF trap compound 57 (7.5 mg/kg) strongly reduced the growth of MM tumor xenografts in vivo, exerted a stronger antitumor activity compared to NSC12.
FGF trap compound 57 induces cell death in both newly diagnosed and relapsed/refractory patient-derived MM cells.
| M.Wt | 554.46 | |
| Formula | C28H21F7O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Taranto S, et al. Pharmacol Res. 2024 Jul 3:107291.
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