| Cat. No. |
Product Name |
Information |
| PC-43499 |
AZD4547
FGFR inhibitor
|
AZD4547 (ADSK091) is a potent and selective inhibitor of FGFR1/2/3 with IC50s of 0.2/1.8/2.5 nM, respectively. |
| PC-45899 |
Dovitinib
Multikinase inhibitor
|
Dovitinib (CHIR-258, TKI258) is a multitargeted RTK inhibitor of class III, IV, and V RTKs with IC50 of 1/2/36/8/9 nM for FLT3/c-KIT/c-Fms/FGFR1/FGFR3, respectively. |
| PC-42173 |
BLU-554
FGFR4 inhibitor
|
BLU-554 (Fisogatinib, BLU554) is a novel potent, highly selective and orally bioavailable inhibitor of FGFR4 with IC50 of 5 nM. |
| PC-45537 |
Erdafitinib
FGFR inhibitor
|
Erdafitinib (JNJ-42756493) is a highly potent and selective, small-molecule inhibitor of FGFR family with IC50s of 1.2/2.5/3/5.7 nM for FGFR1/2/3/4. |
| PC-42406 |
FGF-401
FGFR4 inhibitor
|
FGF-401 (NVP-FGF401, Roblitinib, FGF401) is a first-in-class, potent, highly selective FGFR4 inhibitor with IC50 of 1.1 nM. |
| PC-22316 |
LHQ490
FGFR2 inhibitor
|
LHQ490 is a potent, highly selective fibroblast growth factor receptor 2 (FGFR2) inhibitor with Ic50 of 5.2 nM, >61-, >34-, and >293-fold selective against FGFR1, FGFR3, and FGFR4. |
| PC-21612 |
DW14383
FGFR inhibitor
|
DW14383 is a potent, selective and irreversible inhibitor of FGFR1-4 with IC50 of <0.3 nM, 1.1 nM, <0.3 nM and 0.5 nM for FGFR1/2/3/4 respectively. |
| PC-21321 |
KIN-3248
FGFR inhibitor
|
Resigratinib (KIN-3248) is a next-generation, irreversible, orally available, small molecule pan-FGFR inhibitor with IC50 of 3.9/5.3/9.7 nM for FGFR1/2/3, potently inhibits FGFR2 and FGFR3 gatekeeper, molecular brake, and activation loop mutations with IC50 of 5-20 nM. |
| PC-49580 |
FRS2 ligand 7
FRS2 inhibitor
|
FRS2 ligand 7 is a small molecule ligand of the PTB domain of FGFR proximal adaptor protein FRS2, prevents FRS2 activation and interrupts FGFR signaling, inhibits invasion and tumor growth. |
| PC-49450 |
FGFR2/3 inhibitor 29
FGFR2/3 inhibitor
|
FGFR2/3 inhibitor 29 is a potent and selective inhibitor of wild-type and gatekeeper mutant with IC50 of 0.5 nM (FGFR3). |
| PC-38509 |
PD089828
FGFR inhibitor
|
PD089828 is an ATP competitive inhibitor of FGFR-1, PDGFR-β and EGFR with IC50 of 0.15 uM, 1.76 uM, and 5.47 uM, respectively. |
| PC-38477 |
Alphastatin-C
bFGF inhibitor
|
Alphastatin-C is a 14-amino acids peptide consisting of a C-terminal fragment of the α-chain of Fgn, is a potent inhibitor of bFGF induced endothelial cell (HUVEC-CS) activation in vitro. |
