| Cat. No. |
Product Name |
Information |
| PC-21538 |
ABSK011
FGFR4 inhibitor
|
Irpagratinib (ABSK011) is a potent, selective FGFR4 inhibitor with strong antitumor activity against hepatocellular carcinoma (HCC). |
| PC-21321 |
KIN-3248
FGFR inhibitor
|
Resigratinib (KIN-3248) is a next-generation, irreversible, orally available, small molecule pan-FGFR inhibitor with IC50 of 3.9/5.3/9.7 nM for FGFR1/2/3, potently inhibits FGFR2 and FGFR3 gatekeeper, molecular brake, and activation loop mutations with IC50 of 5-20 nM. |
| PC-49580 |
FRS2 ligand 7
FRS2 inhibitor
|
FRS2 ligand 7 is a small molecule ligand of the PTB domain of FGFR proximal adaptor protein FRS2, prevents FRS2 activation and interrupts FGFR signaling, inhibits invasion and tumor growth. |
| PC-49450 |
FGFR2/3 inhibitor 29
FGFR2/3 inhibitor
|
FGFR2/3 inhibitor 29 is a potent and selective inhibitor of wild-type and gatekeeper mutant with IC50 of 0.5 nM (FGFR3). |
| PC-38509 |
PD089828
FGFR inhibitor
|
PD089828 is an ATP competitive inhibitor of FGFR-1, PDGFR-β and EGFR with IC50 of 0.15 uM, 1.76 uM, and 5.47 uM, respectively. |
| PC-38477 |
Alphastatin-C
bFGF inhibitor
|
Alphastatin-C is a 14-amino acids peptide consisting of a C-terminal fragment of the α-chain of Fgn, is a potent inhibitor of bFGF induced endothelial cell (HUVEC-CS) activation in vitro. |
| PC-38396 |
Gunagratinib
FGFR inhibitor
|
ICP-192 (Gunagratinib) is a novel potent, covalent pan-FGFR (fibroblast growth factor receptors) inhibitor, potently and selectively inhibits FGFR activities irreversibly by covalent binding. |
| PC-72411 |
MAX-40279
FLT3/FGFR inhibitor
|
MAX-40279 (MAX40279, EX-A4057) is a dual inhibitor of FLT3 and FGFR for the treatment of Acute Myeloid Leukemia (AML). |
| PC-72310 |
FGFR4-IN-2
FGFR2 inhibitor
|
FGFR4-IN-2 is a potent, selective, covalent FGFR4 inhibitor with cellualr IC50 of 8.8 nM, 100-fold selectivity over FGFR2. |
| PC-72306 |
FGFR2 inhibitor 38
FGFR2 inhibitor
|
FGFR2 inhibitor 38 is a potent, selective FGFR2 inhibitor with IC50 of 29 nM, exhibits moderate selectivity for FGFR2 over FGFR1/3 (>13.4 fold). |
| PC-72218 |
CPL304110
FGFR inhibitor
|
CPL304110 (CPL-304110) is a selective and potent pan-FGFR inhibitor with IC50 of 0.75 nM, 0.50 nM, 3.05 nM against FGFR1, 2, 3, shows weaken acitvity against FGFR4 with IC50 of 87.9 nM. |
| PC-35145 |
E7090 succinate
|
E7090 (E 7090) is a potent, selective, orally available inhibitor of FGFR1, -2, and -3 with IC50 of 0.71, 0.50 and 1.2 nM, weakly inhibits FGFR4 (IC50=120 nM). |
